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Taking ibuprofen on an empty stomach allows for quicker absorption but does not guarantee a faster pain remedy. Food may delay absorption slightly, but it can additionally assist in protecting the stomach and doubtlessly enhance the general pain-relieving effect. Increased belly inflammation Ibuprofen, like other NSAIDs (nonsteroidal anti-inflammatory pills), can aggravate the belly lining. Taking it on an empty stomach may additionally worsen this effect, leading to pain, heartburn, or maybe gastritis or ulcers.